Journal article
Growth of prefrontal and limbic brain regions and anxiety disorders in children born very preterm
Courtney P Gilchrist, Deanne K Thompson, Bonnie Alexander, Claire E Kelly, Karli Treyvaud, Lillian G Matthews, Leona Pascoe, Diana Zannino, Rosemary Yates, Chris Adamson, Mary Tolcos, Jeanie LY Cheong, Terrie E Inder, Lex W Doyle, Angela Cumberland, Peter J Anderson
PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2023
Abstract
Background Children born very preterm (VP) display altered growth in corticolimbic structures compared with full-term peers. Given the association between the cortiocolimbic system and anxiety, this study aimed to compare developmental trajectories of corticolimbic regions in VP children with and without anxiety diagnosis at 13 years. Methods MRI data from 124 VP children were used to calculate whole brain and corticolimbic region volumes at term-equivalent age (TEA), 7 and 13 years. The presence of an anxiety disorder was assessed at 13 years using a structured clinical interview. Results VP children who met criteria for an anxiety disorder at 13 years (n = 16) displayed altered trajectorie..
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Grants
Awarded by Australian National Health and Medical Research Council (NHMRC) (Centre for Clinical Research Excellence)
Awarded by Australian National Health and Medical Research Council (NHMRC) (Centre for Research Excellence)
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by Financial Markets Foundation for Children Project
Awarded by US National Institutes of Health
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This study was funded by the Australian National Health and Medical Research Council (NHMRC) (Centre for Clinical Research Excellence 546519; Centre for Research Excellence 1060733; Centre for Research Excellence 1153176; Project Grants 237117, 491209 and 1066555; Career Development Fellowships 1085754 and 1160003 [to DKT], 1141354 [to JLYC]; Early Career Fellowship 1012236 [to DKT]; Senior Research Fellowship 1081288 [to PJA]; Leadership Fellowship 1176077 [to PJA]), Financial Markets Foundation for Children Project Grant 2019-083, RMIT Vice Chancellor's Senior Research Fellowship and Australian Research Council Future Fellowship [to MT], Brigham and Women's Hospital Program for Interdisciplinary Neuroscience Fellowship (to LGM), US National Institutes of Health HD058056, United Cerebral Palsy Foundation (USA), Leila Y. Mathers Charitable Foundation (USA), the Brown Foundation (USA), Murdoch Children's Research Institute, the Royal Children's Hospital, The Royal Children's Hospital Foundation, Department of Paediatrics, The University of Melbourne, the Victorian Government's Operational Infrastructure Support Program, and an Australian Government Research Training Program Scholarship [to CG].